The other area of symptomatic improvement in some patients is a reduction in MS-related fatigue. This is, also, not likely due to a direct effect on the MS disease process, but rather an indirect one caused by restoration of normal endorphin levels improving energy.
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Your Recently Viewed Items and Featured Recommendations.Contact the doctor right away if any signs of suicidal thoughts or actions occur. Discuss any questions with the patient s doctor. Naltrexone is not approved for use in children. Talk with the doctor.
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Naltrexone is contraindicated in acute hepatitis or liver failure, and liver function should be monitored during therapy. Treatment is not advised in people who have alanine aminotransferase concentrations greater than 35 times the normal limit.
In the largest study, the most common side effect of naltrexone affected only a small minority of people and included the following: nausea (10 headache (7 dizziness (4 fatigue (4 insomnia (3 anxiety (2 and sleepiness (2). It also may block the "high' feeling that may make you want to use alcohol. It will not produce any narcotic-like effects or cause mental or physical dependence. It will not prevent you from becoming impaired while drinking alcohol.
Naltrexone will cause withdrawal symptoms in people who are physically dependent on narcotics. Naltrexone treatment is started after you are no longer dependent on narcotics. The length of time this takes may depend on which narcotic you took, the amount you took, and how long.
Aside from side effects, which are usually short-lived and mild, patients usually report that they are largely unaware of being on medications. Naltrexone usually has no psychological effects and patients don't feel either "high" or "down" while they are on naltrexone.
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Naltrexone should not be used with pregnant women, individuals with severe liver or kidney damage or with patients who cannot achieve abstinence for at least 5 days prior to initiating medications.
Many pain medications that are not opioids are available for use. If you are going to have elective surgery, naltrexone should be discontinued at least 72 hours beforehand. 14. What Is the relationship of naltrexone to AA?
In clinical trials evaluating the effectiveness of naltrexone, patients who received naltrexone were twice as successful in remaining abstinent and in avoiding relapse as patients who received placebo-an inactive pill. 2.